Invitra Amniotic FluidTM is a biological acellular product derived from the human amnion. Amniotic fluid is rich in growth factors and cytokines including growth factor (EGF), transforming growth factor alpha (TGF alpha), transforming growth factor beta-1, and insulin-like growth factor 1 (IGF1).1 Importantly, amniotic fluid contains factors related to the innate immune system including a spectrum of antimicrobials affective against bacteria, fungi, protozoa, and viruses.2,3
All of our donors are pre-screened through medical record review and evaluation of pre-natal tests. Eligibility is confirmed through behavior risk assessment, physical assessment, donor medical history, review of blood test results, and communicable disease testing. Invitra Amniotic FluidTM is a Human Cellular and Tissue Based Products (HCT/P) as defined by US FDA 21 C.F.R. § 1271.
- Underwood, M. A., Gilbert, W. M., & Sherman, M. P. (2005). Amniotic fluid: not just fetal urine anymore. Journal of perinatology, 25(5), 341-348.
- Akinbi, H. T., Narendran, V., Pass, A. K., Markart, P., & Hoath, S. B. (2004). Host defense proteins in vernix caseosa and amniotic fluid. American journal of obstetrics and gynecology, 191(6), 2090-2096.
- Espinoza, J., Chaiworapongsa, T., Romero, R., Edwin, S., Rathnasabapathy, C., Gomez, R., … & Blackwell, S. (2003). Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine, 13(1), 2-21.