Invitra ATTM is a biological acellular product derived from human amnion. . Amniotic tissue is comprised of an extracellular matrix that forms a natural scaffold. Amniotic tissue has a series of anti-inflammatory, anti-bacterial, anti-viral properties as well as low immunogenicity.1,2 This natural scaffold works as a physical barrier that can contain cells to an affected area by maintaining adhesion of cells.3
- Akinbi, H. T., Narendran, V., Pass, A. K., Markart, P., & Hoath, S. B. (2004). Host defense proteins in vernix caseosa and amniotic fluid. American journal of obstetrics and gynecology, 191(6), 2090-2096.
- Espinoza, J., Chaiworapongsa, T., Romero, R., Edwin, S., Rathnasabapathy, C., Gomez, R., … & Blackwell, S. (2003). Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine, 13(1), 2-21.
- Mamede, A. C., Carvalho, M. J., Abrantes, A. M., Laranjo, M., Maia, C. J., & Botelho, M. F. (2012). Amniotic membrane: from structure and functions to clinical applications. Cell and tissue research, 349(2), 447-458.
All of our donors are pre-screened through medical record review and evaluation of pre-natal tests. Eligibility is confirmed through behavior risk assessment, physical assessment, donor medical history, review of blood test results, and communicable disease testing. Invitra Amniotic ATTM is a Human Cellular and Tissue Based Products (HCT/P) as defined by US FDA 21 C.F.R. § 1271 and is intended for homologous use only as determined by a physician.