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HOME > Our
Products > Invitrx > Invitrx CSS Autologous
Invitrx CSS™
- Autologous
Starts with a biopsy of healthy skin that can range from the size
of a punch biopsy to the size of a postage stamp. The dermal and
epidermal sheets are separated, isolated and grown separately. A
dermal matrix is formed by the fibroblasts, supported by collagen
and Vicryl mesh. Invitrx CSS, a 3-dimensional skin graft, is completed
by the addition of keratinocytes on top of the dermal matrix. Each
graft is custom made and designed to fit the size of the wound with
the average graft being the size of a playing card (5 X 5cm). The
grafts are personally delivered via our medical staff providing
our clients and patients with the highest cellular viability possible
thereby increasing graft take and wound closure.
Invitra CSS, Invitrx’s skin graft product, is
not currently available for commercial use in the United States.
Invitra CSS is available in other world markets outside of the USA,
and is currently under investigation at a number of clinical research
sites to eventually gain FDA approval for marketing in the USA.
Invitrx CSS™ Chronic Wound Applications
Here at Invitrx we believe that our service is just as important
as the quality of our
product. We understand that the viability of the grafts delivered
to our clients is critical, therefore Invitrx excels at providing
high viability products that are coupled with close follow-up
care that facilitates optimum graft take. Our sales and service
departments help instruct hospital personnel and patients
to ensure optimal success of each transplanted graft.
- With a small punch biopsy Invitrx can
construct a custom graft to fit your patients needs.
- Invitrx is a licensed tissue bank, therefore
we can store patient cells if more grafts are needed for
future procedures.
- Invitrx CSS is the only 3-dimensional
autologous composite skin substitute.
Clinical studies have shown
CSS offer reductions in morbidity and mortality for
the treatment of burns and chronic wounds, and for cutaneous
reconstruction1.
Photo of of Invitrx CSS sample
Invitrx CSS™ Burn
Victim Applications
At Invitrx we have a special passion
for the burn victim community. Invitrx CSS was
first developed for this very reason, to provide a safe and
effective way to treat burn victims. With Invitrx CSS, there
is no need for patients to go through the traumatizing procedures
for split-thickness skin grafts and because Invitrx CSS is
autologous, there is no issue of autoimmune rejection.
The requirement for harvesting of donor
skin for CSS was less than for conventional skin autografts.
These results suggest that acute-phase recovery of patients
with extensive burns is facilitated and that complications
are reduced by the use of CSS together with conventional skin
grafting2.
With a biopsy the size of a postage stamp,
Invitrx can grow enough skin to cover a
severely burned patient and deliver it to the attending physician
ready for transplant in three to six weeks.
DISCLAIMER: Invitra CSS, Invitrx’s
skin graft product, is not currently available for commercial
use in the United States. Invitra CSS is available in other
world markets outside of the USA, and is currently under investigation
at a number of clinical research sites to eventually gain
FDA approval for marketing in the USA.
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CSS |
HOME > Our
Products > Invitrx > Invitrx CSS Allogeneous
Invitrx CSS™
- Allogeneous
Invitrx CSS™ Chronic Wound Applications
Here at Invitrx we believe that our service is just as important
as the quality of our
product. We understand that the viability of the grafts delivered
to our clients is critical, therefore Invitrx excels at providing
high viability products that are coupled with close follow-up
care that facilitates optimum graft take. Our sales and service
departments help instruct hospital personnel and patients
to ensure optimal success of each transplanted graft.
- With a small punch biopsy Invitrx can
construct a custom graft to fit your patients needs.
- Invitrx is a licensed tissue bank, therefore
we can store patient cells if more grafts are needed for
future procedures.
- Invitrx CSS is the only 3-dimensional
autologous composite skin substitute.
Clinical studies have shown
CSS offer reductions in morbidity and mortality for
the treatment of burns and chronic wounds, and for cutaneous
reconstruction1.
Photo of of Invitrx CSS sample
Invitrx CSS™ Burn
Victim Applications
At Invitrx we have a special passion
for the burn victim community. Invitrx CSS was
first developed for this very reason, to provide a safe and
effective way to treat burn victims. With Invitrx CSS, there
is no need for patients to go through the traumatizing procedures
for split-thickness skin grafts and because Invitrx CSS is
autologous, there is no issue of autoimmune rejection.
The requirement for harvesting of donor
skin for CSS was less than for conventional skin autografts.
These results suggest that acute-phase recovery of patients
with extensive burns is facilitated and that complications
are reduced by the use of CSS together with conventional skin
grafting2.
With a biopsy the size of a postage stamp,
Invitrx can grow enough skin to cover a
severely burned patient and deliver it to the attending physician
ready for transplant in three to six weeks.
DISCLAIMER: Invitra CSS, Invitrx’s
skin graft product, is not currently available for commercial
use in the United States. Invitra CSS is available in other
world markets outside of the USA, and is currently under investigation
at a number of clinical research sites to eventually gain
FDA approval for marketing in the USA.
back to Invitrx
CSS
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HOME > Our
Products > Invitrx > Invitrx OC
Invitrx OC™
Restores sight by dramatically improving
the visual acuity in patients with ocular surface disorders. Used
for corneal grafts to treat ocular surface diseases.
Invitrx OC™ Corneal Staining
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HOME > Our
Products > Invitrx > Competitive Advantage
Competitve Advantage
We are the only company to provide a 3-D
skin model for the burn and chronic wound markets.
Advantages:
- Autologous: no rejection or chronic
medications needed means better patient care
- High cell viability: local delivery allows immediate healing
and integration resulting in reduced hospital stays
- Post-Op follow-up: patient care though assisting physician and
nursing staff
The chart below illustrates the
advantages of Invitrx products compared to similar products from
other companies.
Clinical Benefits:
- Faster and more complete wound closure
with an increased chance of survival for burn victims treated
with composite skin substitutes (CSS)
- Treatments with CSS can reduce the risk of amputations in patients
with chronic and non-healing wounds.
- Invitrx OC™ is capable of restoring sight by dramatically
improving the visual acuity in patients with ocular surface disorders.
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HOME > Our
Products > Invitrx > Reimbusement Information
Reimbursement Information
For reimbursement regarding our Invitrx™
product line, please contact us at:
877-INVITRX
Monday-Friday, 8am-5pm (PST)
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HOME > Our
Products > Invitrx > Invitrx Logistics
Invitrx™ Process Outline - Autologous Products
The following consists of the general workflow
of the InvitrxTM product lines offered by Invitrx, Inc.
- Specimen Kit Delivery: Set
up an Invitrx™ Specimen Kit delivery date. Please call the
Invitrx, Inc. at (877) 468-4879 or (949) 472-81922.
- Biopsy Pickup: An Invitrx,
Inc. representative will transport the biopsy to our laboratory.
- Graft Delivery: A representative
of Invitrx, Inc., will deliver the graft, at the scheduled time.
- Post Procedure and Follow-up: After
the initial application of the graft, our laboratory staff will
schedule a follow up appointment to access the status of the graft.
Please feel free to call us with any technical help you may need
before, during and after the graft application. We’ll be
there for you and your patient
Invitrx™ Process Outline - Allogeneous Products
The following consists of the general workflow
of the Invitrx™ product lines offered by Invitrx, Inc.
- Place an Order: The products
are ready to go at any time, just call us at (877) 468-4879 to
place an order.
- Graft Delivery: A representative
of Invitrx, Inc., will deliver the graft, at the scheduled time.
- Post Procedure and Follow-up: After
the initial application of the graft, our laboratory staff will
schedule a follow up appointment to access the status of the graft.
Please feel free to call us with any technical help you may need
before, during and after the graft application. We’ll be
there for you and your patient.
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HOME > Our
Products > Invitrx > FAQ's
Invitrx Patient FAQ's
1. Where are my keratinocytes located?
What about my fibroblasts?
Human skin is made up of two areas the dermis and epidermis.
The outer layer called the epidermis is composed mainly of keratinocytes,
while the dermis is composed mostly of fibroblasts and other connective
tissue. By separating the two layers we can then effectively isolate
each of the desired cell types.
2. How are these cell-types harvested?
The donor produces a punch biopsy, which
is obtained by a member of our staff and driven to our nearest lab
site.
3. How much tissue is needed from the patient
in order to get a good yield of cells?
The amount of tissue needed for our product
is insignificant when compared to current standard split thickness
protocols to harvest autologous tissue.
4. Is the viability of the cells affected
by the age of the donor?
The viability of certain cell types is affected
by the passage of time. Usually younger cells are more healthy and
reproductive than their older siblings.
5. What happens to cells that might be left
over after my procedure?
We guarantee efficient and responsible use
of your personal tissue while it is under our care. Secondly, we
will accomplish this task through maintaining firm roots that strive
to hold a new standard of GMP and QC.
6. Will my cells be used for research purposes?
Your cells will only be used to form custom
grafts for your personal wound closure. If any cells remain in the
lab, the donor will be notified and informed of our intentions.
Also, Chronic wounds may require freezing a small stock that could
be stored and thawed when needed months later.
7. Can the cells taken from my biopsy be
used for only me? What about another family member?
Our products are autologous which means that
the cells from our product are the same as the donor’s own
cells. The family member should not use the graft constructed for
you because of an exponentially higher chance for the graft to fail.
8. How long can our cell types remain in storage?
We believe that the cells will remain viable
for at least 2.5 years in a standard liquid nitrogen cooler.
9. How can you be sure that the cells will
be viable once frozen?
Our team has a lot of experience maintaining
these cell populations and this direct knowledge is what we believe
and implement when forming our standard protocols.
10. Where will they be stored?
The cells will all be stored at the Invitrx
facility in Irvine, CA.
11. Will a blackout affect the stored keratinocytes
and fibroblasts?
Since the storage system for our patient
cells is kept cool by liquid nitrogen, a loss of electricity would
not effect the system.
12. How long will you maintain my cells?
Our team is dedicated to closing wounds and
we will not stop until your wounds have closed entirely and the
healing process can resume.
13. How can I get technical support?
Just fill out our tech support form
and a support person will contact you to help you with any questions
or difficulties you may have.
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HOME > Our
Products > Invitrx > Products in Pipeline
Products in Pipeline
- Cell-based dry-eye formulation is currently undergoing clinical
trials at the University of Sao Paolo Dept. of Ophthalmology.
- Anti-aging, anti-wrinkle cream under development.
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